ELTE - Drosophila Ageing and Neurodegeneration Group

N6-Methyladenine Progressively Accumulates in Mitochondrial DNA during Aging

Sturm Á, Sharma H, Bodnár F, Aslam M, Kovács T, Németh Á, Hotzi B, Billes V, Sigmond T, Tátrai K, Egyed B, Téglás-Huszár B, Schlosser G, Charmpilas N, Ploumi C, Perczel A, Tavernarakis N, Vellai T

Int J Mol Sci. 2023 Oct 3;24(19):14858

DOI: 10.3390/ijms241914858

Downregulation of transposable elements extends lifespan in Caenorhabditis elegans

Ádám Sturm, Éva Saskői, Bernadette Hotzi, Anna Tarnóci, János Barna, Ferenc Bodnár, Himani Sharma, Tibor Kovács, Eszter Ari, Nóra Weinhardt, Csaba Kerepesi, András Perczel, Zoltán Ivics & Tibor Vellai

Nat Commun 14, 5278 (2023)

DOI: 10.1038/s41467-023-40957-9

Potent New Targets for Autophagy Enhancement to Delay Neuronal Ageing

Szinyákovics J, Keresztes F, Kiss EA, Falcsik G, Vellai T, Kovács T

Cells. 2023 Jun 30;12(13):1753

DOI: 10.3390/cells12131753

The Small-Molecule Enhancers of Autophagy AUTEN-67 and -99 Delay Ageing in Drosophila Striated Muscle Cells

Komlós M, Szinyákovics J, Falcsik G, Sigmond T, Jezsó B, Vellai T, Kovács T

Int J Mol Sci. 2023 Apr 30;24(9):8100

DOI: 10.3390/ijms24098100

A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging

Tibor Kovács, Janka Szinyákovics, Viktor Billes, Gábor Murányi, Virginia B. Varga, Annamária Bjelik, Ádám Légrádi, Melinda Szabó, Sára Sándor, Enikő Kubinyi, Cecília Szekeres-Paracky, Péter Szocsics, János Lőke, Jun Mulder, Balázs Gulyás, Éva Renner, Miklós Palkovits, Károly Gulya, Zsófia Maglóczky & Tibor Vellai

Sci Rep 12, 21817 (2022)

DOI: 10.1038/s41598-022-24843-w

Autophagy is required for spermatogonial differentiation in the Drosophila testis

Varga VB, Schuller D, Szikszai F, Szinyákovics J, Puska G, Vellai T, Kovács T

Biol Futur. 2022 Jun;73(2):187-204

DOI: 10.1007/s42977-022-00122-7

The evolutionary and functional divergence of the Atg8 autophagy protein superfamily

Virginia B. Varga, Fanni Keresztes, Tímea Sigmond, Tibor Vellai & Tibor Kovács

BIOLOGIA FUTURA 73, 375-384

DOI: 10.1007/s42977-022-00123-6

Trehalose-releasing nanogels: A step toward a trehalose delivery vehicle for autophagy stimulation

Ali Maruf, Małgorzata Milewska, Tibor Kovács, Máté Varga, Tibor Vellai, Anna Lalik, Sebastian Student, Olga Borges, Ilona Wandzik

Biomaterials Advances, Volume 138, 2022, 212969,

DOI: 10.1016/j.bioadv.2022.212969

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky DJ, Abdelmohsen K, Albert ML,... Banhegyi G, Juhasz G, Kapuy O, Kovacs T, Lekli I, Lorincz P, Megyeri K, Nagy P, Orosz L, Petrovski G, Takacs-Vellai K, Takats S, Vellai T, Vertessy BG,... Zughaier SM.

Autophagy. 2021 Jan;17(1):1-382

DOI: 10.1080/15548627.2020.1797280

Condition-dependent functional shift of two Drosophila Mtmr lipid phosphatases in autophagy control

Anna Manzéger, Kinga Tagscherer, Péter Lőrincz, Henrik Szaker, Tamás Lukácsovich, Petra Pilz, Regina Kméczik, George Csikós, Miklós Erdélyi, Miklós Sass, Tibor Kovács, Tibor Vellai & Viktor A. Billes

Autophagy, 17:12, 4010-4028

DOI: 10.1080/15548627.2021.1899681

Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/Gα(i/o)

Kutnyánszky V, Hargitai B, Hotzi B, Kosztelnik M, Ortutay C, Kovács T, Győry E, Bördén K, Princz A, Tavernarakis N, Vellai T

Mol Genet Genomics. 2020 Mar;295(2):357-371

DOI: 10.1007/s00438-019-01625-0

The nucleoside diphosphate kinase NDK-1/NME1 promotes phagocytosis in concert with DYN-1/Dynamin

Farkas Z, Petric M, Liu X, Herit F, Rajnavölgyi É, Szondy Z, Budai Z, Orbán TI, Sándor S, Mehta A, Bajtay Z, Kovács T, Jung SY, Afaq Shakir M, Qin J, Zhou Z, Niedergang F, Boissan M, Takács-Vellai K

FASEB J. 2019 Oct;33(10):11606-11614

DOI: 10.1096/fj.201900220R

Highly efficient RNAi and Cas9-based auto-cloning systems for C. elegans research

Ádám Sturm, Éva Saskői, Kovács Tibor, Nóra Weinhardt, Tibor Vellai

Nucleic Acids Research, Volume 46, Issue 17, 28 September 2018, Page e105

DOI: 10.1093/nar/gky516

Developmentally regulated autophagy is required for eye formation in Drosophila

Billes V, Kovács T, Manzéger A, Lőrincz P, Szincsák S, Regős Á, Kulcsár PI, Korcsmáros T, Lukácsovich T, Hoffmann G, Erdélyi M, Mihály J, Takács-Vellai K, Sass M, Vellai T.

Autophagy. 2018;14(9):1499-1519

DOI: 10.1080/15548627.2018.1454569

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms.

Kovács T, Billes V, Komlós M, Hotzi B, Manzéger A, Tarnóci A, Papp D, Szikszai F, Szinyákovics J, Rácz Á, Noszál B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, Tárnok K, Schlett K, Borsy A, Welker E, Kovács AL, Pádár Z, Erdős A, Legradi A, Bjelik A, Gulya K, Gulyás B, Vellai T

Scientific Reports 2017 Feb 16;7:42014

DOI: 10.1038/srep42014

AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects

Diána Papp, Tibor Kovács, Viktor Billes, Máté Varga, Anna Tarnóci, László Hackler Jr, László G Puskás, Hanna Liliom, Krisztián Tárnok, Katalin Schlett, Adrienn Borsy, Zsolt Pádár, Attila L Kovács, Krisztina Hegedűs, Gábor Juhász, Marcell Komlós, Attila Erdős, Balázs Gulyás & Tibor Vellai

Autophagy, 12:2, 273-286

DOI: 10.1080/15548627.2015.1082023

AUTEN-67 (Autophagy Enhancer-67) Hampers the Progression of Neurodegenerative Symptoms in a Drosophila model of Huntington's Disease

Billes V, Kovács T, Hotzi B, Manzéger A, Tagscherer K, Komlós M, Tarnóci A, Pádár Z, Erdős A, Bjelik A, Legradi A, Gulya K, Gulyás B, Vellai T

Journal of Huntington's disease. 5. 133-147.

DOI: 110.3233/JHD-150180

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky DJ, Abdelmohsen K, Albert ML, Bánhegyi G, Juhász G, Kapuy O, … Kovács T, … Lekli I, Lőrincz P, Megyeri K, Nagy P, Orosz L, Petrovski G, Takács-Vellai K, Takáts S, Vellai T, Vertessy BG, Zughaier SM

Autophagy pp. 1-222.

DOI: 10.1080/15548627.2015.1100356

Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans

Péter Erdélyi, Éva Borsos, Krisztina Takács-Vellai, Tibor Kovács, Attila L. Kovács, Tímea Sigmond, Balázs Hargitai, Líz Pásztor, Tanima SenGupta, Marlene Dengg, Ildikó Pécsi, Judit Tóth, Hilde Nilsen, Beáta G. Vértessy, Tibor Vellai

Journal of Cell Science 124, 1510-1518.

DOI: 10.1242/jcs.080192